Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult Participants

Inclusion Criteria:

- Participants who has given, personally signed, and dated informed consent to
participate in the study, in accordance with the International Conference on
Harmonization Good Clinical Practice Guideline E6 (1996) and applicable regulations,
before completing any study-related procedures.

- Age 18-45 years inclusive at the time of consent. The date of signing informed consent
is defined as the beginning of the Screening Period. This inclusion criterion will be
assessed only at the Screening Visit.

- Male, or non-pregnant, non-lactating female who agrees to comply with any applicable
contraceptive requirements of the protocol or females of non-childbearing potential. A
female of non-childbearing potential (defined as a female who is post-menopausal
[amenorrhea for at least 12 consecutive months], has had a hysterectomy, bilateral
tubal ligation, bilateral oophorectomy or bilateral salpingectomy.

- Satisfactory medical assessment with no clinically significant or relevant abnormal
findings as determined by medical/surgical history, physical examination, vital signs,
12-lead electrocardiogram, and clinical laboratory evaluation (hematology,
biochemistry, thyroid function, and urinalysis) that are likely to interfere with the
participant's participation or ability to complete the study as assessed by the
investigator.

- An understanding, ability, and willingness to fully comply with study procedures and
restrictions.

- Body mass index (BMI) between 18.5 and 30.0 kilograms per square meter (kg/m^2)
inclusive; assessed only at the screening visit.

- Able to swallow (multiple capsules or tablets at 1 time or consecutively at 1 time)
all investigational product.

- Healthy as determined by the investigator on the basis of screening evaluations.

Exclusion Criteria:

- Current or recurrent disease or conditions (example: cardiovascular, renal, liver,
gastrointestinal, malignancy or other conditions) that could affect the absorption,
action, or disposition of either omeprazole or anagrelide or its metabolites, or could
affect clinical assessments or clinical laboratory evaluations.

- Current or relevant history of physical or psychiatric illness, any medical disorder
that may require treatment or make the participant unlikely to fully comply with the
requirements of the study or complete the study, or any condition that presents undue
risk from the investigational product or study procedures.

- Significant illness, as judged by the investigator, within the 2 weeks of
administration of the first dose of investigational product.

- Use of any medication (including prescription, over-the-counter, herbal, multivitamin,
oral contraceptives and other hormonal contraceptive treatments, or homeopathic
preparations) within the 30 days prior to the first dose of study drug or during the
study through Day 9 (occasional use of acetaminophen is allowed).

- Treatment with any known hepatic and/or P450 enzyme-altering agents, including CYP1A2
inducers or inhibitors within 30 days prior to the first dose of investigational
product. This includes: Strong inhibitor- ciprofloxacin, enoxacin, fluvoxamine, and
zafirlukast; Moderate inhibitor- methoxsalen, mexiletine, and oral contraceptives;
Moderate inducer- phenytoin, rifampin, ritonavir, smoking, teriflunomide; Inducer-
lansoprazole

- A history of any of the following medical conditions:

1. History of previous bone marrow suppression.

2. History of hypersensitivity to the investigational product.

3. History of adverse hematologic reaction, (such as neutropenia, thrombocytopenia,
anemia) to any drug.

4. History of symptomatic or clinically meaningful orthostatic hypotension or
syncope, as assessed by the investigator.

5. History of controlled or uncontrolled hypertension or a systolic blood pressure
greater than or equal to (>=) 140 millimeters of mercury (mmHg) or diastolic
blood pressure >= 90 mmHg at the Screening Visit or Day -1.

6. Participant has any history of seizure disorder.

7. History or presence of known structural cardiac abnormalities, syncope, cardiac
conduction problems (PR interval greater than (>) 220 milliseconds (ms), second
or third-degree heart block, bundle branch block [except congenital right bundle
branch block], or prolonged QTc interval) or exercise-related cardiac events.

8. History of alcohol or other substance abuse within the last year.

- A participant's alcohol consumption that fulfils one of the following: (Note: One
alcohol unit=1 beer [12 ounce {oz}]=1 wine [5 oz]=1 liquor [1.5 oz])

1. Has consumed alcohol within 2 days prior to the first dose of investigational
product.

2. Male participants who consume more than 3 units of alcohol per day.

3. Female participants who consume more than 2 units of alcohol per day.

- Positive screening test results for alcohol, drugs of abuse, or pregnancy (females of
childbearing potential only) at the Screening Visit or Day -1.

- A positive human immunodeficiency virus (HIV) antibody screen, hepatitis B surface
antigen (HBsAG) or hepatitis C virus antibody (HCV) screen.

- Use of tobacco in any form (smoking or chewing) or other nicotine-containing products
in any form (gum, patch) within 30 days prior to the first dose of investigational
product and during the in-house stay at the CRC.

- A positive urine cotinine test that is >= 50 Nano grams per milliliter (ng/mL) at
either the Screening Visit or on Day -1.

- Routine consumption of more than 2 units of caffeine per day or participants who
experience caffeine-withdrawal headaches or have a history of caffeine-withdrawal
headaches. (One caffeine unit is contained in the following items: one 6-oz cup of
coffee, two 12-oz cans of cola, one 12-oz cup of tea, and three 1-oz chocolate bars.
Decaffeinated coffee, tea, or cola are not considered to contain caffeine.)

- Consumption of grapefruit, Seville oranges, and/or products containing these items
within 7 days prior to the first dose of investigational product.

- Donation of blood or blood products (egg, plasma, or platelets) within 60 days prior
to the first dose of investigational product.

- Known or suspected intolerance or hypersensitivity to the investigational products
(anagrelide or omeprazole) or closely related compounds, or any of the stated
ingredients.

- Within 30 days prior to the first dose of investigational product:

1. Have used an investigational product (if elimination half-life is <6 days,
otherwise 5 half-lives).

2. Have been enrolled in a clinical study (including vaccine studies) that, in the
Investigator's opinion, may impact this Shire-sponsored study.

- Prior screen failure, participation, or enrollment in this study.

- History of sensitivity to heparin or heparin-induced thrombocytopenia.