The Natural History of Injury-Related Disuse Osteopenia
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Osteoporosis, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Rheumatology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 3/23/2019 |
| Start Date: | May 31, 2017 |
| End Date: | May 1, 2020 |
Determine the severity and time course (natural history) of disuse osteopenia that occurs in
the lower extremity(ies) and lumbar spine of patients sustaining lower extremity injuries
that require the patient to maintain restricted weight bearing status (12 weeks) following
the surgical fixation of the patient's injuries.
The investigators hypothesize that there will be a significant decrease in the bone mineral
density in the lower limbs of patients undergoing restricted weight bearing for
peri-articular injuries of the lower extremity. This loss of bone mineral density is often
prolonged in its duration and may lower subsequent fracture threshold and prolong the time to
recovery and return to activities.
the lower extremity(ies) and lumbar spine of patients sustaining lower extremity injuries
that require the patient to maintain restricted weight bearing status (12 weeks) following
the surgical fixation of the patient's injuries.
The investigators hypothesize that there will be a significant decrease in the bone mineral
density in the lower limbs of patients undergoing restricted weight bearing for
peri-articular injuries of the lower extremity. This loss of bone mineral density is often
prolonged in its duration and may lower subsequent fracture threshold and prolong the time to
recovery and return to activities.
It is well documented that restricted weight bearing even for relatively short periods (12
weeks) associated with the surgical treatment of peri-articular injuries of the lower
extremity (ie acetabulum, distal femur, tibial plateau, pilon, talus, calcaneus) can lead to
a measurable decrease in bone density in the injured limb. Furthermore, this osteopenia can
persist for extended periods of time - much longer than the original period of restricted
weight bearing. This relative osteopenia can delay recovery from injury, lower fracture
threshold for subsequent injury and potentially delay return to active duty in the case of a
wounded warrior. There exists a significant body of research in the modulation of the
osteopenia associated with restricted weight bearing as it pertains to long term space flight
(microgravity).
weeks) associated with the surgical treatment of peri-articular injuries of the lower
extremity (ie acetabulum, distal femur, tibial plateau, pilon, talus, calcaneus) can lead to
a measurable decrease in bone density in the injured limb. Furthermore, this osteopenia can
persist for extended periods of time - much longer than the original period of restricted
weight bearing. This relative osteopenia can delay recovery from injury, lower fracture
threshold for subsequent injury and potentially delay return to active duty in the case of a
wounded warrior. There exists a significant body of research in the modulation of the
osteopenia associated with restricted weight bearing as it pertains to long term space flight
(microgravity).
Inclusion Criteria:
1. Age 18-70 at time of injury
2. Previously normal community ambulator (without ambulatory aid) prior to injury
Exclusion Criteria:
1. Presence of a total or hemi hip prosthesis in the injured extremity
2. Presence of lumbar fusion L1-L4
3. Previous ipsilateral lower extremity trauma
4. History of medical treatment for known osteoporosis (Calcium and Vitamin D
supplementation alone is NOT an exclusion criteria)
5. Ambulatory dysfunction prior to injury
6. Inability to cooperate with DXA scanning
7. Head injury on admission requiring invasive monitoring or treatment
8. Inability to adhere to weight bearing restrictions
9. Inability to provide consent
10. Non English speaking
11. Pregnancy
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