Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment
| Status: | Recruiting |
|---|---|
| Conditions: | Atrial Fibrillation |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/10/2019 |
| Start Date: | March 1, 2017 |
| End Date: | December 31, 2027 |
| Contact: | Anson Lee, MD |
| Email: | ansonlee@stanford.edu |
| Phone: | 650-724-7500 |
Assessment of Intra-Operative Atrial Fibrillation Inducibility As a Screening Tool to Prevent Post-Operative Atrial Fibrillation With Prophylaxis Amiodarone
Patients undergoing first time cardiac surgery underwent rapid atrial pacing prior to
initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible
AF were randomized to prophylactic amiodarone treatment versus no treatment. Patients who
were not inducible to AF were treated with standard post-operative care. Patients were
monitored post-operatively to explore the value of intraoperative inducibility of AF to
predict POAF and to evaluate whether the combination of intraoperative inducibility and
precision amiodarone therapy is effective at reducing the incidence of POAF
initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible
AF were randomized to prophylactic amiodarone treatment versus no treatment. Patients who
were not inducible to AF were treated with standard post-operative care. Patients were
monitored post-operatively to explore the value of intraoperative inducibility of AF to
predict POAF and to evaluate whether the combination of intraoperative inducibility and
precision amiodarone therapy is effective at reducing the incidence of POAF
Inclusion Criteria: Patients seeking first-time non-emergent open-heart surgery for
coronary artery bypass graft (CABG) revascularization, valvular repair or replacement,
combined CABG with valve repair or replacement, or valve sparing aortic root repair in
normal sinus rhythm with no documented history of atrial fibrillation -
Exclusion Criteria: prior surgical procedures involving heart surgery and cardiopulmonary
bypass; any prior documented history of atrial fibrillation, atrial flutter or atrial
tachycardia lasting longer than 30 seconds; prior history of Amiodarone treatment for the
management of supraventricular tachy-arrhythmias; and subjects requiring surgical treatment
of atrial arrhythmias such as pulmonary vein isolation or Maze procedure.
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