Dose Effect of a Plant Extract on Fatigue

Inclusion Criteria:

- 18-49 years of age

- Self-report of good health

- Physical activity requirement: Recreationally active (exercise ≥3 times per week for
>30 minutes per session; both cyclists and non-cyclists may enroll)

Exclusion Criteria:

- Under the care of a physician

- Visual impairment that cannot be corrected with glasses or contact lenses

- Inability to perform high intensity exercise (defined perceptually as exercise that
feels at least "hard" and this is usually quantified using the Borg 6 to 20 scale.
High intensity cycling exercise is defined objectively as exercise causing a high
heart rate, defined as a heart rate that is equal to or greater than 70% of heart rate
reserve.)

- Inability to adequately perform the cognitive tasks (i.e., cannot complete the task
due to -inability to understand instructions or >50% incorrect responses)

- Presence of current or chronic gastrointestinal, sleep or psychiatric disorder

- Pregnant/lactating

- Current smoker

- Report illegal drug use

- Report hypersensitivity to caffeine

- Food allergies/intolerances/sensitivities (including coffee or related
foods/beverages/products)

- Current use of dietary supplements, or prescription medication except for oral
contraceptives

- Unwillingness to abstain from over the counter medications (e.g. NSAIDS, allergy
medications) and caffeine/coffee/foods high in polyphenols for 12 hours prior to the
study

- Unwilling to refrain from consuming apple and grapefruit products on study days and 12
hours prior to test days.

- Participation in another clinical trial within the past 30 days or participation in
another PepsiCo trial in the past 6 months