Functional Assessment in Liver Transplantation
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/14/2019 |
| Start Date: | October 6, 2015 |
| End Date: | December 2020 |
| Contact: | Karen D Castro |
| Email: | karen.castro@BSWHealth.org |
| Phone: | 214-820-6243 |
In order to ensure the equity of the liver allocation process, it is important to create
objective, scientifically validated markers of frailty in patients with end-stage liver
disease that accurately predict patient outcomes. Many measures have been developed to assess
this clinical state in elderly patients, but none have been applied to patients with
cirrhosis, a population at increased risk for accelerated functional decline. This protocol
is designed to learn more about the effects of functional status (also known as "frailty") in
liver transplant patients and patient outcomes both before and after liver transplant.
objective, scientifically validated markers of frailty in patients with end-stage liver
disease that accurately predict patient outcomes. Many measures have been developed to assess
this clinical state in elderly patients, but none have been applied to patients with
cirrhosis, a population at increased risk for accelerated functional decline. This protocol
is designed to learn more about the effects of functional status (also known as "frailty") in
liver transplant patients and patient outcomes both before and after liver transplant.
Subjects in this study will be asked questions regarding functional status and ability to do
activities at home. Subjects will also be asked to complete several physical tests to assess
functional status. For example, subjects will be asked to stand up from a chair several
times, balance with their feet together, and walk down a hall as quickly as possible.
Subjects will also be asked to perform a hand grip strength test.
Subjects will be assessed at baseline and at every clinic visit in the pre-transplant
setting. Subjects will again be assessed at 3, 6, and 12 months post-transplant.
activities at home. Subjects will also be asked to complete several physical tests to assess
functional status. For example, subjects will be asked to stand up from a chair several
times, balance with their feet together, and walk down a hall as quickly as possible.
Subjects will also be asked to perform a hand grip strength test.
Subjects will be assessed at baseline and at every clinic visit in the pre-transplant
setting. Subjects will again be assessed at 3, 6, and 12 months post-transplant.
Inclusion Criteria:
- Adults (≥18 years old)
- Listed for liver transplantation, or are "listable" - i.e, have undergone formal
evaluation and been approved for listing if/when patients achieve high enough priority
- Are seen in the outpatient clinic setting
Exclusion Criteria:
- Have severe hepatic encephalopathy at enrollment (defined by the time to complete the
Numbers Connection Test (NCT) > 120 seconds, which is the first test that the
participants complete upon enrollment).
We found this trial at
1
site
3500 Gaston Avenue
Dallas, Texas 75246
Dallas, Texas 75246
1.800.422.9567
Phone: 214-820-6243
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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