Multicenter Bone and Joint Health Study

MOST study participants in the "Existing Cohort" (3,026 subjects) were enrolled in the
original study in 2003-2005. Surviving Existing Cohort participants without end-stage knee
osteoarthritis will be asked to participate in the 144-, 152-, 160- and 168-month follow-up
contacts. In addition, in 2016-2018 the cohort will be enriched by the recruitment of an
additional 1,500 "New Cohort" participants with early or mild knee symptoms. The goal of the
study is to find novel strategies to prevent disease at an early stage.

Inclusion Criteria for "New Cohort" Participants:

- Age 45 to 69 Years (Adult, Senior)

- Males and Females

- Healthy Volunteers

- Community-based Sample

Exclusion Criteria for "New Cohort" Participants:

- Rheumatoid or inflammatory arthritis (based on self-report and use of medications
specific to these conditions)

- Serious health condition e.g., end-stage renal disease, etc. that would likely limit
follow-up to less than 2-3 years

- Plan to relocate out of geographic region in next 3 years

- Not able to walk without the aid of a person or assistive device

- Knee joint replacement surgery in either knee

- Neither knee fits in the MRI knee coil (determined during Screening Visit).

- Not competent to give informed consent

- Advanced structural tibiofemoral or patellofemoral knee OA disease (KL grade 3 or 4)
in either knee (Determined by Knee X-ray Screening)