Acute Labetalol Use in Preeclampsia
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/15/2019 |
| Start Date: | February 18, 2019 |
| End Date: | July 1, 2021 |
| Contact: | Asha Rijhsinghani |
| Email: | rijhsia@amc.edu |
| Phone: | 518.262.4942 |
Acute Labetalol Use in Preeclampsia Randomized Trial
The purpose of this study is to understand if administration of a personalized dose of the
anti-hypertensive medication, labetalol, based on patient's body-mass index, will be more
effective at controlling severe hypertension during pregnancy, compared to the current
standard dosing.
anti-hypertensive medication, labetalol, based on patient's body-mass index, will be more
effective at controlling severe hypertension during pregnancy, compared to the current
standard dosing.
The investigators seek to asses the effect of obesity (BMI>30) on severe hypertension control
in patients with preeclampsia with severe features. The investigators hypothesize that
successive administration of 40-60-80 mg of labetolol will reduce time to blood pressure
control versus the standard dosing, 20-40-80 mg labetolol, recommended by the American
College of Obstetricians and Gynecologists in 2015.
in patients with preeclampsia with severe features. The investigators hypothesize that
successive administration of 40-60-80 mg of labetolol will reduce time to blood pressure
control versus the standard dosing, 20-40-80 mg labetolol, recommended by the American
College of Obstetricians and Gynecologists in 2015.
Inclusion Criteria:
- BMI ≥ 30
- Age ≥ 18 years
- Gestational age ≥ 24 weeks
- Singleton gestation
- One sustained severe range blood pressure at Albany Medical Center
Exclusion Criteria:
- Known allergic reaction to labetlol
- Persistent mild-moderate asthma (≥ 2 rescue inhaler uses per week in the previous
month)
- Obstructive airway disease
- Bradycardia < 70 beats/min
- Heart block > 1st degree or history of heart failure
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