This is a Prospective Evaluation of ProChondrix CR for the Repair of Articular Cartilage Defects on the Femoral Condyle and Patella

Inclusion Criteria:

- Patient is ≥18 and ≤ 60 years old at the time of surgery;

- Symptomatic patient presenting with moderate to severe pain in the index knee -
unresponsive to conservative treatment (i.e. medication, bracing, physical therapy)
and/or previous surgical intervention;

- Radiographically diagnosed, by MRI, or through arthroscopy, to have a cartilage defect
on the femoral condyle or patella between ≥ 1 cm2 and ≤ 5 cm2, measured as a rectangle
length x width;

- Will be having a marrow stimulation plus ProChondrix CR procedure;

- Has an intact meniscus (maximum of ≤50% resected);

- Have the ability to understand the requirements of the study, to provide written
informed consent, and to comply with the study protocol.

Exclusion Criteria:

- Has > 5° of varus or valgus deformity;

- Bipolar articular cartilage involvement (kissing lesions) of the ipsilateral
compartment (i.e. > than ICRS Grade 2 on the opposing articular surface);

- Associated damage to the underlying subchondral bone >2 mm requiring osseous repair;

- Requires concomitant ligament repair other than Anterior Cruciate Ligament (ACL) or
Medial Patella-Femoral Ligament (MPFL) reconstruction;

- Body Mass Index (BMI)of ≥ 35 kg/m2;

- Active malignancy: undergoing treatment for tumor or boney traumatic injury or a
history of any invasive malignancy (except non-melanoma skin cancer), unless the
patient has been treated with curative intent and there have been no clinical signs or
symptoms of the malignancy for at least 5 years;

- Clinical and/or radiographic disease in the affected joint that includes:
osteoarthritis or avascular necrosis, gout or a history of gout or pseudogout,
osteochondritis dissecans with significant bone loss;

- Cartilage lesion location such that the implanted graft will not be adequately
shouldered;

- Active local microbial infection or a systemic infection, including prior or pending
treatment for HIV, syphilis, Hepatitis B or Hepatitis C;

- Currently immunologically suppressed or immunocompromised, or a medical condition
requiring radiation, chemotherapy or immunosuppression;

- Unstable cardiovascular, renal, hepatic, endocrine and/or pulmonary disease, cancer or
uncontrolled diabetes;

- Has a history of any inflammatory or connective tissue disease, such as, systemic
lupus erythematosus (SLE), Addison's disease, Crohn's disease, multiple sclerosis,
polychondritis or rheumatoid arthritis;

- Received hyaluronic acid injections into the joint space ≤ 90 days prior to surgery;

- Is a female patient who is pregnant;

- Physically or mentally compromised (i.e. being currently treated for a psychiatric
disorder, senile dementia, Alzheimer's disease) in a manner that would compromise
his/her ability to participate in the clinical study;

- Has a history of substance abuse (recreational drugs, alcohol) or has been treated in
the last 6 months before enrollment for alcohol and/or drug abuse in an in-patient
substance abuse program;

- Patients who, in the opinion of the Investigator, would not be able or willing to
comply with the protocol;

- Is currently involved in a study of another investigational product for similar
purpose or has been in the previous 90 days;

- Has any contraindications for MRI;

- Is a ward of the state, prisoner, or transient.