Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function

Hemodialysis patients who have residual kidney function will undergo two 4-week study (twice
weekly versus thrice weekly hemodialysis). Blood, urine, and dialysate samples will be
collected at the end of each study period to determine adequacy of treatment and to assess
uremic solute levels. Participants will complete quality of life questionnaires and cognitive
paper tests. Food records and medications may be monitored.

Inclusion Criteria:

- Stable dialysis patients able to provide consent

Exclusion Criteria:

- Use of antibiotics for last two months or expected antibiotic use

- Recent hospitalization or other event resulting in instability of food intake

- Residual kidney function < 2.5 mL/min