The TOGETHER Project - Liver

The study is a prospective, observational study utilizing peripheral blood assays that will
be collected at time points that are considered standard of care at most institutions. 100
participants will be enrolled in study. Participants will have peripheral blood collected at
4 months and 12 months after liver transplant, as well as any for cause time points.
Participants will also have liver biopsies collected at these time points. The results from
the liver biopsies will be used in correlation with the results from the peripheral blood
assays.

Inclusion Criteria:

- Patients who have given informed consent and are willing to comply with the protocol,
including the use of their peripheral blood specimens and data for subsequent
research.

- Patients with increased risk of rejection. Patients must meet at least one of the
following criteria:

1. Autoimmune etiology of the original liver disease (autoimmune hepatitis, primary
biliary cirrhosis or primary sclerosing cholangitis)

2. Recipients of donation-after-cardiac death (DCD) donors

3. Recipients of simultaneous liver-kidney transplantation

4. Positive crossmatch liver transplant (T cell flow crossmatch or B cell flow
crossmatch).

Exclusion Criteria:

- Adult ( ≥ = 18 years) renal transplant recipient.