Neural Mechanisms of Mindfulness-based Cognitive Therapy (MBCT) for Posttraumatic Stress Disorder (PTSD)

Status:	Not yet recruiting
Conditions:	Psychiatric, Psychiatric
Therapuetic Areas:	Psychiatry / Psychology
Healthy:	No
Age Range:	18 - 72
Updated:	3/16/2019
Start Date:	March 2019
End Date:	December 2020
Contact:	Elizabeth Hinckley, BA
Email:	ehinckly@med.umich.edu
Phone:	734-764-9527

This study will examine the effects of psychotherapy as treatment for PTSD. This research
will see how brain activity and brain connectivity is affected by Mindfulness Based Cognitive
Therapy (MBCT) and Muscle Relaxation Therapy (MRT). Participants that qualify to be in this
study will receive 8 weeks of group therapy in MBCT or MRT. Prior to receiving therapy
participants will: complete baseline assessments related to their PTSD; fill out surveys;
have an functional magnetic resonance imaging (fMRI); and provide a saliva sample. These
assessments will be repeated after the therapy is over. Overall study participation should
last approximately 10-12 weeks.

Inclusion Criteria:

- Meets current Diagnostic and Statistical Manual of Mental Disorders, fifth edition
(DSM-5) criteria for PTSD (with or without Major Depressive Disorder); type of trauma
is not restricted and can include interpersonal violence, combat, and sexual assault,
etc.

Exclusion Criteria:

- Dissociative PTSD

- Delayed-onset PTSD

- Magnetic Resonance Imaging (MRI) contraindications (e.g. metal in body, inability to
be in the scanner - claustrophobia, severe back pain, etc.)

- Serious medical or neurologic conditions (e.g. stroke, seizures)

- Suicide risk

- Psychosis

- Life history of schizophrenia

- Life history of bipolar disorder

- Current substance dependence

- Other factors that preclude safe and meaningful participation in the study, at
discretion of the PI and study team

We found this trial at

sites

VA Ann Arbor Healthcare System

Ann Arbor, Michigan 48113

Phone: 734-764-9527

from

Ann Arbor, MI