Stimulation to Undermine Dementia

This research study is being done to learn important information about the effects of weak
electrical stimulation on brain functioning in those with mild cognitive impairment (MCI).
The findings will help determine "how much" stimulation is needed to enhance memory and
thinking abilities, how it affects brain functioning, and who is most likely to benefit.
Ultimately, this information may guide treatment efforts for those at various stages of
Alzheimer's disease. The study will use brain imaging to see whether these treatments change
how participants learn and remember information. Functional magnetic resonance imaging (fMRI)
and positron emission tomography (PET) scans will be used. The study will also use cognitive
tests and questionnaires to examine whether participants' memory (and related abilities)
change because of treatment. The study will enroll participants with a diagnosis of MCI. It
is expected that participants will be co-enrolled in the University of Michigan Memory and
Aging Project (UM-MAP; HUM00000382).

Inclusion Criteria:

1. Diagnosis of Mild Cognitive Impairment

2. Right-handed

3. Must be MRI compatible, criteria that also apply for High Definition transcranial
direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants
in the upper body or head)

4. Stable on relevant medications for at least 4 weeks prior to study enrollment

Exclusion Criteria:

1. Certain neurological diseases

2. Certain psychiatric conditions

3. Severe sensory impairment