Dietary Oxalate and Immune Cell Function
| Status: | Recruiting |
|---|---|
| Conditions: | Nephrology, Nephrology |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 3/17/2019 |
| Start Date: | September 21, 2016 |
| End Date: | September 2021 |
| Contact: | Tanecia Mitchell, PhD |
| Email: | taneciamitchell@uabmc.edu |
| Phone: | 205-996-2292 |
The purpose of this study is to evaluate mitochondrial function in white blood cells and
platelets from healthy individuals following dietary oxalate intake.
platelets from healthy individuals following dietary oxalate intake.
Inflammation and dietary oxalate have been shown to play an important role in the development
of kidney stones. Oxalate is a small molecule found in plants and plant-derived food.
Individuals that have high oxalate intake have an increased risk of developing kidney stones.
The co-investigators have previously shown that healthy subjects that consume dietary oxalate
have increased plasma and urine oxalate.
White blood cells are essential for the immune response and rely on the mitochondria to carry
out important cell functions. The Principal Investigator's current research shows that
patients with calcium oxalate kidney stones have decreased mitochondrial function in their
immune cells. Using the expertise of the investigators, this study will test whether oxalate
has a direct effect on mitochondrial function in immune cells from healthy subjects. This
information could help us understand the role of oxalate on the immune system during kidney
stone pathogenesis.
of kidney stones. Oxalate is a small molecule found in plants and plant-derived food.
Individuals that have high oxalate intake have an increased risk of developing kidney stones.
The co-investigators have previously shown that healthy subjects that consume dietary oxalate
have increased plasma and urine oxalate.
White blood cells are essential for the immune response and rely on the mitochondria to carry
out important cell functions. The Principal Investigator's current research shows that
patients with calcium oxalate kidney stones have decreased mitochondrial function in their
immune cells. Using the expertise of the investigators, this study will test whether oxalate
has a direct effect on mitochondrial function in immune cells from healthy subjects. This
information could help us understand the role of oxalate on the immune system during kidney
stone pathogenesis.
Inclusion Criteria:
- Mentally competent adults who are able to read and comprehend the consent form,
written in English
- Male or Female
- Age 18 to 70 years
- Non-tobacco users
- BMI between 19 and 27
- Willingness to abstain from vigorous exercise during study period
- Normal blood comprehensive metabolic panel
Exclusion Criteria:
- Mentally incompetent adults who are unable to read or comprehend the consent form,
written in English
- Pregnant females
- Active medical problems
- History of kidney stones
- Any medical disorder that could influence absorption or excretion of oxalate
- BMI less than 19 or greater than 27
- Tobacco users
- Current use of medications or dietary supplements
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