Efficacy and Safety of BMS-986165 Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA)



Status:Not yet recruiting
Conditions:Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:3/21/2019
Start Date:March 29, 2019
End Date:December 31, 2020
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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A Randomized, Placebo-Controlled, Double-blind, Multicenter Study to Assess the Efficacy and Safety of Multiple Doses of BMS-986165 in Subjects With Active Psoriatic Arthritis (PsA)

The main purpose of study is to assess the dose-response relationship of BMS-986165 (Dose A
or Dose B once daily [QD]) at Week 16 in the treatment of participants with active PsA.

The study is intended to evaluate the safety and efficacy of BMS-986165 Dose A or B once
daily (QD) compared with placebo in adults with active PsA. The primary endpoint is american
college of rheumatology (ACR) 20 response at Week 16 (Part A).

Inclusion Criteria:

- Diagnosed with PsA for at least 6 months before screening, and who meet the
Classification Criteria for Psoriatic Arthritis (CASPAR) at screening

- Participants either (i) cannot have prior exposure to biologics (biologic-naïve) or
(ii) have failed or been intolerant to 1 tumor necrosis factor -inhibitor (TNFi)
(TNFi-experienced). Failure is defined as lack of response or loss of response with at
least 3 months of therapy with an approved dose of a TNFi, as judged by the
investigator. Failure must have occurred at least 2 months prior to Day 1

- Participants have at least 1 confirmed greater than or equal to (>=) 2 centimeter (cm)
lesion of plaque psoriasis at screening

- Participants have active arthritis as shown by a minimum of >= 3 swollen joints and >=
3 tender joints (66/68 joint counts) at screening and Day 1

- High sensitivity C-reactive protein (hsCRP) >= 3milligram per liter (mg/L) at
screening

- Women of Childbearing Potential (WOCBP) must have a negative serum or urine pregnancy
test within 24 hours prior to the start of study treatment

Exclusion Criteria:

- Has non-plaque psoriasis (that is (i.e.), guttate, inverse, pustular, erythrodermic or
drug-induced psoriasis) at screening or Day 1

- Has any other autoimmune condition such as rheumatoid arthritis, etc. There are
exceptions for inflammatory bowel disease or uveitis as follows: currently active
disease is excluded but, a history of no longer active disease for at least 12 months
(including not being on medication) is allowed

- Has active (i.e. currently symptomatic) fibromyalgia

- History or evidence of active infection and/or febrile illness within 7 days prior to
Day 1 (example, bronchopulmonary, urinary, gastrointestinal, etc.)

- History of recent serious bacterial, fungal, or viral infections requiring
hospitalization and intravenous (IV) antimicrobial treatment within 90 days prior to
screening, or any infection requiring antimicrobial treatment within 15 days prior to
Day 1

- History of active tuberculosis (TB) prior to screening visit, regardless of completion
of adequate treatment
We found this trial at
19
sites
Plantation, Florida 33324
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Plantation, FL
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2630 Northeast 203rd Street
Aventura, Florida 33180
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Aventura, FL
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2388 Mcfaddin Avenue
Beaumont, Texas 77702
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Beaumont, TX
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Charlotte, North Carolina 28203
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Charlotte, NC
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DeBary, Florida 32713
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DeBary, FL
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1200 4th Avenue
Duncansville, Pennsylvania 16635
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Duncansville, PA
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Hlucin, 74801
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Hlucin,
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Lebanon, New Hampshire 03756
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Lebanon, NH
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Lexington, Kentucky 40536
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Lexington, KY
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Memphis, Tennessee 38103
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Memphis, TN
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Miami Lakes, Florida 33016
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Miami Lakes, FL
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Middleburg Heights, Ohio 44130
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Middleburg Heights, OH
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Salisbury, North Carolina 28144
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Salisbury, NC
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San Antonio, Texas 78229
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San Antonio, TX
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San Diego, California 92123
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San Diego, CA
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2363 Lakewood Road
Toms River, New Jersey 08755
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Toms River, NJ
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Whittier, California
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Whittier, CA
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Wichita, Kansas 67214
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Wichita, KS
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Worcester, Massachusetts 01608
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Worcester, MA
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