A Study to Compare Pharmacokinetic and Safety of TRS003 to China-approved Bevacizumab and US-licensed Avastin®

The primary assessment of PK similarity will be based upon a 90 percentage confidence
interval (CI) for the ratio of the geometric means (TRS003, China-approved bevacizumab and
US-licensed Avastin®) for AUC0-inf on PK analysis set. If the 90 percentage CI of the ratio
of the geometric means for AUC0-inf is within the range of 80-125 percentage, then PK
similarity will be concluded. Secondary PK parameters such as but not limited to Cmax,
AUClast will be analyzed using the same statistical approach. A nonparametric approach, for
example, Wilcoxon signed-rank test, will be taken to evaluate parameters such as t1/2.
Exploratory analyses may be performed for other PK parameters as deemed appropriate. All
adverse events (AEs) will be listed and summarized using descriptive methodology. The
incidence of AEs for each treatment will be presented by severity and association with the
study drugs. Clinical laboratory parameters, vital signs, and electrocardiogram (ECG)
parameters will be listed and summarized using descriptive statistics. The number and
percentage of participants testing positive for anti-drug antibodies (ADAs) will be
summarized by treatment and time point.

Inclusion Criteria:

- Healthy, male participants, 18-55 years old with no significant medical history, and
in good health as determined by detailed medical history, full physical examination,
vital signs, 12-lead electrocardiogram (ECG), urinalysis and laboratory tests at
screening.

- Body mass index of 17.5-30.5 kg/m^2 and body weight of 50-95 kg.

- Protocol-specified hematology, coagulation, blood chemistry and urinalysis within the
laboratory normal range at screening, unless deemed not clinically significant by the
Investigator.

- Participants must have adequate organ function according to the following laboratory
values:

1. Bone marrow function (absolute neutrophil count ≥1500/mm^3 and platelet count
≥100,000/mm^3)

2. Adequate liver function [alanine aminotransferase (ALT) ≤3 × upper limit normal
(ULN) and alkaline phosphatase ≤2 × ULN, total bilirubin ≤1.5 mg/dL]

3. Adequate renal function creatinine clearance ≥60 mL/min based on Cockcroft-Gault
equation

- Participants must agree to use an acceptable form of birth control throughout the
study and for at least 18 weeks after the study is over.

Exclusion Criteria:

- Participants unable to give voluntary informed consent.

- Evidence or history of clinically significant disease, cancer other than adequately
treated basal cell or squamous cell carcinoma of the skin.

- Participants on anticoagulant drugs, anemic or with known bleeding diatheses.

- Participants with a history of severe, uncontrolled hypertension, heart disease,
cerebrovascular incidents, gastrointestinal bleeding, hemoptysis, frequent epistaxis
or gingival bleeding.

- History clinically significant orthostatic hypotension, fainting spells, vasovagal
syncope.

- Uncontrolled severe hypertension (140/90 mm Hg).

- Previous treatment with an anti-VEGF antibody or any other antibody or protein
targeting the VEGF receptor.

- Use of any prescription, investigational drugs, herbal supplements or nonprescription
drugs within 1 month or 5 half-lives (whichever is longer) prior to the first dose, or
dietary supplements within 1 week prior to the first dose. If needed,
paracetamol/acetaminophen may be used, but must be documented in the Concomitant
medications/Significant non-drug therapies page of the case report form (CRF).

- Serious unhealed wound, cutaneous ulcer or bone fracture at the time of screening.

- Major surgery or major dental procedure or significant traumatic injury within 2
months prior to screening, or any planned surgery or procedure within 3 months after
investigational treatment administration. Participants must have recovered from all
acute surgery- or trauma-related complications.

- Participant's medical and family history of recent or recurrent thromboembolism or
other clotting and coagulation disorders.

- Donated blood over 400 mL within 3 months.

- History of relevant and clinically significant intra-abdominal inflammation,
gastrointestinal perforation or gall bladder perforation.

- History of severe allergic or anaphylactic reaction to a therapeutic drug or severe
seasonal allergies.

- Recent (within the last three [3] years) and/or recurrent history of acute or chronic
bronchospastic disease (including asthma and chronic obstructive pulmonary disease,
treated or not treated).

- A positive hepatitis B, hepatitis C or HIV tests at screening indicative of a current
or past infection.

- Current use of tobacco or nicotine-containing products. Concomitant treatment was
given only if Investigator believes strictly necessary and should be documented.

- Current use of any biologic drugs.