The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI

This multilevel study will be comprised of a placebo controlled randomized controlled trial
to test the effect of long-term (6 months), multi-domain, computerized cognitive training on
large-scale structural and functional brain networks in individuals with MCI (age >= 65
years). Neuroimaging and neuropsychological data before and after intervention will be
evaluated within and between groups to elucidate the trajectory of neuronal network
improvements associated with training compared to typical MCI development. We will compare
the outcomes between participants with MCI who receive structured cognitive training
(treatment group: TG) with those who receive nonspecific computerized training activities
(active controls: AC). The duration of intervention is 6 months. The focus of the study will
be on individuals with amnestic MCI (single- or multi- domain). The study includes 30 MCI
subjects in a treatment group (TG) and 30 matched MCI subjects in active control (AC) group.
TG and AC participants will be evaluated at two time points: 1) baseline and 2) 6-month
(post-training).

Inclusion criteria:

- Cognitive concern by subject, informant or physician

- Impairment in memory domain (delayed recall of one paragraph from Logical Memory II
subscale from Wechsler memory Scale - Revised with cutoff scores of <=8, <=4 and <=2
for 16, 8-15 and 0-7 years of education)

- Essentially normal functional activities

- Mini-Mental State Examination (MMSE) scores >=24

- Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension
medication, etc.) for at least two months.

Exclusion criteria:

- Any significant neurological condition including probable dementia, Parkinson's
disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.

- Presence of Axis I disorder

- Current use of psychoactive medications except for the permitted medications.

- Claustrophobia

- MRI contraindication

- Any significant systemic or unstable medical condition which could lead to difficulty
complying with the protocol.