Loratadine for Improvement of Bone Pain in Patients With Chronic Granulocyte-Colony Stimulating Factor (G-CSF) Use
| Status: | Not yet recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 12 - 99 |
| Updated: | 3/22/2019 |
| Start Date: | April 2019 |
| End Date: | October 2019 |
| Contact: | Lauren Merz |
| Email: | lemerz@umich.edu |
| Phone: | 616-550-2734 |
G-CSF causes a release of histamine that may be a cause of chronic bone pain. Loratadine
targets histamine, and so may be effective in reducing bone pain.The researchers plan to
prospectively assess the effectiveness of loratadine for chronic bone pain in patients with
chronic G-CSF use.
targets histamine, and so may be effective in reducing bone pain.The researchers plan to
prospectively assess the effectiveness of loratadine for chronic bone pain in patients with
chronic G-CSF use.
Inclusion Criteria:
- Diagnosis of neutropenia
- Granulocyte-colony stimulating factor (G-CSF) use for at least 3 months at least 4
times per month
- Mean bone pain of at least a 2/10 as assessed by questions 3-6 of the Brief Pain
Inventory (BPI)
Exclusion Criteria:
- Other sources of chronic pain
- Previously tried loratadine for 7 consecutive days or more for bone pain
- Allergy to loratadine
- Chronic daily usage of antihistamine without an acceptable alternative
non-antihistamine medication
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