U01-Biomarkers for Noninvasive and Early Detection of Pancreatic Cancer

This is an observational, biospecimen collection protocol to develop a bank of pancreatic
cancer tissue, normal tissue. Biospecimens collected through this protocol will be shared
with collaborators in the Pancreatic Cancer Detection Consortium to support projects funded
through an NIH U01 grant. Participants will be enrolled when they present for clinically
indicated surgical procedures for their possible tumor or pancreas resection or cyst
resection, or at a clinically indicated follow-up appointment after their procedure.

This protocol supports this effort by providing investigators with access to a wide variety
of pancreatic tissues and biospecimens for translational studies in pancreatic cancer. This
protocol covers the collection of clinical data and biospecimens (blood; malignant, benign,
or precancerous pancreatic tumor; and adjacent normal tissues) from patients with, or
suspected to have, pancreatic cancer. Additionally, saliva and cyst fluid, may be collected
in the future from patients with pancreatic cysts. These will be shared with the Pancreatic
Cancer Detection Consortium for further analysis.

Inclusion Criteria:

- Males or Females ≥ 18 years of age who have been diagnosed with Pancreatic Cancer
(PDAC), Pancreatic Neoplasms (PNs - IPMMs, PanINs and MCNs), pancreatitis and diabetes
or no disease/healthy.

- Individuals undergoing or have previously undergone a diagnostic procedure (i.e. EUS
or ERCP) evaluation or surgery.

- Willingness and ability to donate biospecimens for the purpose of research.

- Subjects must have had diagnostic procedure or surgery after September 1, 2017.

Exclusion Criteria:

- Individuals under 18 years of age.

- Inability to donate biospecimens.

- Females pregnant or lactating.