Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Alzheimer Disease, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 65 - 85 |
| Updated: | 3/28/2019 |
| Start Date: | August 2019 |
| End Date: | November 30, 2023 |
| Contact: | Melissa Harris, PhD |
| Email: | Melissa.Harris@pbrc.edu |
| Phone: | 225763091 |
The RAATE proposal is designed to determine the effects of physical activity on risk factors
for Alzheimer's Disease in older African American adults. The study will compare a physical
activity program to an active control group. There are three main objectives of the protocol:
1) to determine if a physical activity intervention tailored to older African American adults
is effective in modifying cognitive function associated with Alzheimer's Disease, 2) to
determine if a physical activity intervention tailored to older African American adults is
effective in modifying brain function and structure associated with Alzheimer's Disease, and
3) to determine if a physical activity promotion intervention tailored to African American
adults is effective at enhancing physiological parameters. The primary endpoints for the
study are episodic memory and executive functioning. The secondary outcomes include
anthropometry, blood pressure, brain activation, cerebral blood flow, volume of whole brain
and white matter hyperintensities, cardiorespiratory fitness, objectively measured physical
activity, circulating hormones, and telomere length.
for Alzheimer's Disease in older African American adults. The study will compare a physical
activity program to an active control group. There are three main objectives of the protocol:
1) to determine if a physical activity intervention tailored to older African American adults
is effective in modifying cognitive function associated with Alzheimer's Disease, 2) to
determine if a physical activity intervention tailored to older African American adults is
effective in modifying brain function and structure associated with Alzheimer's Disease, and
3) to determine if a physical activity promotion intervention tailored to African American
adults is effective at enhancing physiological parameters. The primary endpoints for the
study are episodic memory and executive functioning. The secondary outcomes include
anthropometry, blood pressure, brain activation, cerebral blood flow, volume of whole brain
and white matter hyperintensities, cardiorespiratory fitness, objectively measured physical
activity, circulating hormones, and telomere length.
Inclusion Criteria:
1. self- identify as African American
2. 65 - 85 years of age
3. willing to accept randomization
4. willing to attend group sessions
5. lacking plans to move during the study period
6. free of conditions that would make regular exercise unsafe (e.g. uncontrolled asthma,
severe sickle cell disease, etc.)
7. not engaged in regular physical activity
8. score >/=27 on the Mini-Mental State Examination, and 9) a Short Physical Performance
Battery score >/= 4
9. physically capable of exercise,
Exclusion Criteria:
1. cognitive impairment that would interfere with participating in group interactions
2. unwilling to give written informed consent
3. inability to attend group sessions
4. conditions that prevent regular exercise
5. conditions that the medical or principal investigator determine to warrant exclusion
We found this trial at
1
site
6400 Perkins Rd
Baton Rouge, Louisiana 70808
Baton Rouge, Louisiana 70808
(225) 763-2500
Principal Investigator: Robert L Newton, Jr., PhD
Phone: 225-763-3091
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