Liver Health and Metabolic Function in People With Obesity

Non-alcoholic fatty liver disease (NAFLD) affects approximately 70% of those with obesity and
if left untreated can progress to cirrhosis and liver failure. NAFLD stages progress from the
stage of simple steatosis to steatohepatitis, and fibrosis The stage of NAFLD is currently
best determined using histology from a liver biopsy, however this provides a static depiction
of the state of the liver. Therefore This project aims to determine fibrogenesis in the liver
of obese humans in vivo, before and after weight loss.

Inclusion Criteria:

- Body mass index ≥35 kg/m2

- Scheduled for Bariatric surgery

Exclusion Criteria:

- Significant organ disfunction/disease

- Tobacco use

- Previous bariatric surgery

- Pregnancy

- Excessive alcohol use

- Liver disease other than NAFLD