Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients



Status:Terminated
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 89
Updated:4/21/2016
Start Date:June 2008
End Date:August 2013

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy And Safety Trial Of Bapineuzumab (Aab-001, Eln115727) In Subjects With Mild to Moderate Alzheimer Disease Who Are Apolipoprotein E 4 Non-carriers

This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in
patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab
or placebo. Each patient's participation will last approximately 1.5 years.


Inclusion Criteria:

- Diagnosis of probable Alzheimer Disease (AD), with Mini Mental State Examination
(MMSE) score of 16-26, and brain magnetic resonance imaging (MRI) consistent with the
diagnosis of AD

- Concurrent use of cholinesterase inhibitor or memantine allowed, if stable

- Caregiver will participate and be able to attend clinic visits with patient

Exclusion Criteria:

- Significant neurological disease other than AD

- Major psychiatric disorder

- Contraindication to undergo brain MRI [e.g., pacemaker, cerebrospinal fluid (CSF)
shunt, or foreign metal objects in the body]

- Women of childbearing potential
We found this trial at
161
sites
Comprehensive Clinical Research
175 Cross Keys Rd.
Berlin, New Jersey 08009
856-753-7335
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Alpine Clinical Research Center
1000 Alpine
Boulder, Colorado 80304
303-443-7229
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University of North Texas Health Science Center
3500 Camp Bowie Boulevard
Fort Worth, Texas 76107
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MD Clinical
911 E. Hallandale Beach Blvd
Hallandale Beach, Florida 33009
954-455-5757
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Renstar Medical Research
104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
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Compass Research LLC
100 West Gore St # 202
Orlando, Florida 32806
(407) 426-9299
Compass Research LLC Compass Research is a clinical research company dedicated to testing new medications...
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Hospital of the University of Pennsylvania
3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
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Innovative Clinical Trials
5430 Fredericksburg Road
San Antonio, Texas 78229
210-377-2873
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Integra Clinical Research
3603 Paesanos Parkway
San Antonio, Texas 78231
210-614-4884
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Stedman Clinical Trials
3212 Cove Bend Drive
Tampa, Florida 33613
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Neurology & Neuroscience Center of Ohio
1000 Regency Court
Toledo, Ohio 43623
419-841-7369
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Chase Medical Research, LLC
500 Chase Parkway
Waterbury, Connecticut 06708
203-419-4420
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Waterbury, CT
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Abington Memorial Hospital
1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Abington Neurological Associates
Abington, Pennsylvania 19001
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University of Michigan Health System
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
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University of Michigan Hospital
Ann Arbor, Michigan 48109
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Clinical Study Center of Asheville, LLC
Asheville, North Carolina 28803
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NeuroTrials Research, Incorporated
Atlanta, Georgia 30342
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JEM Research Institute
Atlantis, Florida 33462
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Medical Specialists of the Palm Beaches
Atlantis, Florida 33462
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Austin Infusion Centers
Austin, Texas 78756
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Senior Adults Specialty Research
Austin, Texas 78757
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Southwestern Vermont Healthcare
Bennington, Vermont 05201
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The Memory Clinic
Bennington, Vermont 05201
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Foers Medical Arts Pharmacy
Bethesda, Maryland 20814
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Bringham and Women's Hospital
Boston, Massachusetts 02115
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General Clinical Research Center
Boston, Massachusetts 02118
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Boston University
One Silber Way
Boston, Massachusetts 02215
(617) 353-2000
Boston University Boston University is no small operation . With over 33,000 undergraduate and graduate...
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IDS Pharmacy
Boston, Massachusetts 02118
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Pacific Medical Centers
Bothell, Washington 98021
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Associated Neurologists, PC
Boulder, Colorado 80304
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Bradenton Research Center, Incorporated
Bradenton, Florida 34205
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Northeast Radiology
Brewster, New York 10509
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Brewster, NY
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Cemic University Hospital
Buenos Aires,
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Medical University of South Carolina Hospitals and Clinics
Charleston, South Carolina 29425
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Medical University of South Carolina Investigational Drug Service
Charleston, South Carolina 29425
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Alzheimer's Memory Center
Charlotte, North Carolina 28211
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University of Virginia Neurology
Charlottesville, Virginia 22903
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University Of Virginia General Clinical Research Center
Charlottesville, Virginia 22908
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University of Viriginia Investigational Pharmacy
Charlottesville, Virginia 22908
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Columbus Diagnostic Center (MRI)
Columbus, Georgia 31901
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Medical Research and Health Education Foundation, Incorporated
Columbus, Georgia 31909
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Ohio State University Imaging at Martha Morehouse
Columbus, Ohio 43210
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The Ohio State University Hospitals Clinic
Columbus, Ohio 43210
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Ohio State University Medical Center
Columbus, Ohio 43210
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Ohio State University
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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Neurology Clinic, PC
Cordova, Tennessee 38018
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ATP Clinical Research, Incorporated
Costa Mesa, California 92626
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Texas Neurology, PA
Dallas, Texas 75214
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Associated Neurologists, P.C.
Danbury, Connecticut 06810
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Dekalb Neurology Associates, LLC/NeuroStudies.net, LLC
Decatur, Georgia 30033
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NeuroStudies.net
Decatur, Georgia 30033
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North Broward Medical Center
Deerfield Beach, Florida 33064
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Brain Matters Research
Delray Beach, Florida 33445
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Mile High Research Center
Denver, Colorado 80218
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Michigan State University
East Lansing, Michigan 48824
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Rhode Island Mood & Memory Research Institute
East Providence, Rhode Island 02914
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Memory Enhancement Center of America, Inc.
Eatontown, New Jersey 07724
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Alexian Brothers Medical Center
Elk Grove Village, Illinois 60007
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Alexian Brothers Neurosciences Institute
Elk Grove Village, Illinois 60007
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Elkhart Clinic, LLC
303 S Nappanee St
Elkhart, Indiana 46514
(574) 296-3200
Elkhart Clinic, LLC Informed participation in the management of your health care maximizes your Elkhart...
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Pharmacology Research Institute
Encino, California 91316
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Associated Neurologists of Southern Connecticut, PC
Fairfield, Connecticut 06824
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Marty's Pharmacy
Flowood, Mississippi 39232
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Precise Research Centers
Flowood, Mississippi 39232
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Neurologic Consultants, PA
Fort Lauderdale, Florida 33308
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Margolin Brain Institute
Fresno, California 93720
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Dedicated Clinical Research
Goodyear, Arizona 85395
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Advanced Neurology Specialists
Great Falls, Montana 59405
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Spectrum Home Solutions
Great Falls, Montana 59405
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Bendheim Cancer Center
Greenwich, Connecticut 06830
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Center for Healthy Aging
Greenwich, Connecticut 06830
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Radiant Research, Incorporated
Greer, South Carolina 29651
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Hattiesburg Clinic
Hattiesburg, Mississippi 39401
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ActivMed Practices and Research
Haverhill, Massachusetts 01830
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Clinical Trials of America, Incorporated
Hickory, North Carolina 28601
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The Compounding Pharmacy
Hickory, North Carolina 28602
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The Clinical Trial Center, LLC
Jenkintown, Pennsylvania 19046
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The Center for Pharmaceutical Research, P.C.
Kansas City, Missouri 64114
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Infusion Care Pharmacey
Laguna Hills, California 92653
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Senior Clinical Trials, Incorporated
Laguna Hills, California 92653
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Lake Charles Clinical Trials LLC
Lake Charles, Louisiana 70601
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Michigan State University
409 West Circle Drive
Lansing, Michigan 48910
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Neurostudies.net
Lawerenceville, Georgia 30045
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Neurostudies.net
Lawrenceville, Georgia 30046
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Clinical Trials, Inc.
Little Rock, Arkansas 72205
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Neurological Care of Central New York
Liverpool, New York 13088
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Liverpool, NY
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Faculty Physicians and Surgeons of Loma Linda University School of Medicine
Loma Linda, California 92354
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Loma Linda University Medical Center
11234 Anderson St
Loma Linda, California 92354
(909) 558-4000
Loma Linda University Medical Center An outgrowth of the original Sanitarium on the hill in...
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Collaborative Neuroscience Network, Inc.
Long Beach, California 90806
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Pharmacology Research Institute
Los Alamitos, California 90720
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Alzheimer's Research Corporation
Manchester, New Jersey 08759
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Psychology Associates
Mishawaka, Indiana 46545
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The Institute for Neurodegenerative Disorders
New Haven, Connecticut 06510
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Yale University School of Medicine
333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
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Yale-New Haven Hospital
20 York St, N20 York St,
New Haven, Connecticut 06520
(203) 688-4242
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Norman S. Werdiger, MD
New Haven, Connecticut 06519
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Institutional Review Board / Ethics Committee
New Haven, Connecticut 06520
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