We conduct Phase IA, I, and IIA clinical research studies. Various types of studies have been conducted at Healthcare Discoveries Inc., including experience with thorough QTc and other cardiac services, first in human, pilot, single and multiple dose escalation, PK, PD, bioequivalence, food/drug interaction, MTD, ethnicity effects, age/gender, intravenous infusion testing, and renal impaired.

In addition, we have access to over 300 dialysis patients (GFR <15); approximately 700 pre dialysis subjects (GFR 15-30) ; 2000 patients with moderate impairment (GFR 30-60); and 1500 patients with mild impairment (GFR 60-90). Our subject database of over 5000 healthy/normal, and other special populations, such as Type I and II diabetics, glucose intolerant, obese, and ethnic population (e.g. Spanish, Indian, and Japanese), can accommodate rapid enrollment for most any Phase I study design.

Our physicians at Healthcare Discoveries, Inc. excel at complex pharmacology studies that require difficult diagnostic procedures (e.g. Glucose Clamping, EEG studies, gastric and esophageal pH monitoring, esophagogastroduodenoscopies, etc.) and time sensitive sampling.

Highlights include:

• On-site pharmacy and pharmacist
• On-site CLIA and COLA certified laboratory
• eCRF (EDC)- sponsor involvement in eCRF design
• Central IRB (1 week turn-around)
• Recruitment department and toll-free call center (Hotline: 877-848-7425) [Special population (disease and healthy)]

Our sister company, Catalyst Pharmaceutical Research, LLC, is a full service CRO that can provide data management, statistical support, medical writing, monitoring, and more. See Catalyst website for more details: www.catalystpharmagroup.com

We can speed both the initiation and completion of your Phase I research because our Phase I facilities are part of the Catalyst Pharma Group (CPG) family. Together, Healthcare Discoveries and Catalyst provide the perfect foundation for accelerating clinical development and a smooth transition from Phase I to Phase II through Phase III clinical studies. With over 10 years experience in all phases of clinical research, across the spectrum of medical science, we have designed our Phase I operations to provide the most professional, confidential, and secure environment possible to protect both the subject's and client's interests.

Client List
Healthcare Discoveries Inc. has worked with the following Sponsors and CRO's:

Dennis A. Ruff, M.D., Medical Director, President

Specialty: Internal Medicine

Education:

Doctor of Medicine
Albany Medical College of Union University
Albany, NY 1982

Lafayette College
Easton, PA 1974-78

Boards:

National Boards Part I, II, & III Passed 1980-83
FLEX Part II, Passed 1985

Credentials:

Certification - American Board of Internal Medicine 1985 Licensed

Research Experience Summary:

• Duration: Over 20 years
• Clinical Trials Conducted - over 300
• Phases: I-IV
• Principal Investigator on studies covering healthy volunteers, and diseased population including: hypertension, diabetes, OA, CHF, CAD, lipids, MI, AFIB, COPD, IBS, PVD, dyspepsia, erosive esophagitis, pain, and several others

Positions:

• Medical Director, Catalyst Pharma Group, CRO and clinical research site, 2004-present
• Medical Director, Healthcare Discoveries, San Antonio. clinical research site, 1994-present
• Research Physician, South Texas Clinical Trials. A clinical research site, 1985-1994
• Solo Practice, San Antonio, 1988-present
• Southwest Medical Group, San Antonio, 1985-87
• Residency and Internship in Internal Medicine, Allentown Affiliate Hospitals, 1982-85

Appointments:

Chairman, Pharmacy and Therapeutic Committee, San Antonio Community/Regional Hospital, 1996-98; Member 1994-95
Member, Bioethics Committee, San Antonio Regional Hospital, 1993-94
Chairman, Dept. of Internal Medicine, Humana Hospital, San Antonio, 1990
Chairman, Joint Bioethics Committee, St. Luke's & Methodist Hospitals, 1988-89

Academic:

Clinical Professor, Dept. of Medicine, University of Texas Health Science Center, San Antonio, TX - Current

Awards:

From a site management organization:

• Excellence in Research, 1997
• Management Award, 1997

Publications:

Ten research publications

Emanuel DeNoia, M.D., Vice President

Specialty: Internal Medicine

Education:

Doctor of Medicine
College of Medicine of New Jersey
Newark, New Jersey - 1975

Credentials:

Eligible - American Board of Internal Medicine 1975 Licensed

Research Experience Summary:

• Duration: Over 10 years
• Clinical Trials Conducted: over 175
• Phases: I-IV
• Clinical Investigator on studies covering healthy volunteers, and diseased population including: hypertension, diabetes, OA, CHF, CAD, lipids, MI, AFIB, COPD, IBS, PVD, dyspepsia, erosive esophagitis, pain, and several others

Positions:

• Research Physician/Clinical Investigator, Healthcare Discoveries, Inc., San Antonio clinical research site 1995-present
• Solo Practice, San Antonio 1979-2005
• Solo Practice, Shrewsbury, New Jersey 1978-1979
• Residency, Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey 1976-1978
• Internship Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey 1975-1976

Appointments:

Associate Attending Monmouth Medical Center, Long Branch, New Jersey 1979

Hospital/Professional Affiliations:

San Antonio Community Hospital, San Anotnio, TX 1981-present
St. Luke's Lutheran Hospital, San Antonio, TX 1981-present
Southwest Texas Methodist Hospital, San Antonio, TX 1981-present
Associate A.C.P.
Texas Medical Associate
Bexar County Medical Society
Board of Directors, San Antonio Regional Hospital
Head of Internal Medicine, San Antonio Regional Hospital
Membership Committee, St. Luke's PHO, San Antonio, TX

Medical Director:

Christus Santa Rosa Hospice, San Antonio, TX present
Vistacare Hospice, San Antonio, TX 1995-2006
Four Seasons Nursing Home, San Antonio, TX
Lytle Nursing Home, Lytle, TX
Northgate Manor Nursing Home, San Antonio, TX

George Atiee, M.D.

Specialty: Family Practice

Education:

Doctor of Medicine
U.T. Health Science Center
San Antonio, TX 1981

Credentials:

Certification - American Board of Family Practice 1988 Licensed

Research Experience Summary:

• Duration: Over 10 years
• Clinical Trials Conducted: over 90
• Phases: I-IV
• Clinical Investigator on studies covering healthy volunteers, and diseased population including: hypertension, diabetes, OA, CHF, CAD, lipids, MI, AFIB, COPD, IBS, PVD, dyspepsia, erosive esophagitis, pain, and several others

Positions:

• Research Physician/Clinical Investigator, Healthcare Discoveries, Inc., San Antonio clinical research site 2005-present
• Research Physician/Clinical Investigator, Sun Research Institute, San Antonio clinical research site 1995-2003
• Private Practice, San Antonio, TX 2000-present
• Family Practice Physician, WellMed, San Antonio, TX 1999-2000
• Family Practice Physician, Cinnamon Creek Medical Group, San Antonio, TX 1993-1999
• Family Practice Physician, Trinity Medical Group, San Antonio, TX 1991-1992
• Residency, Baylor College of Medicine, Houston, TX (Co-Chief Resident third year of residency) 1986-1988
• Internship, Baylor College of Medicine, Houston, TX 1985-1986

Military Experience:

Air Force Active Duty 1980-1991
Chief of Primary Care Clinic, Randolph Air Force Base, San Antonio, TX

Medical Societies:

Bexar County Medical Society
Texas Medical Association
Texas Academy of Family Physicians
American Academy of Family Physicians

San Antonio, Texas, area has a population of about 1.2 million. Per the Wikipedia the eight-county metropolitan area has a population of over 1.8 million. San Antonio is the second-most populous cioty in the state of Texas after Houston and seventh-most populated in the United States. San Antonio is home to 12+ major universities and community colleges and the largest concentration of military bases in the United States. Racial make up of San Antonio consist of 64% White, 61.% African American, 1.8% Asian, 0.7% Native Americna; 61.2% of the population is of Hispanic origin and could be of any race. The population is spread out with 28.5% under the age of 18, 10.8% from 18-24, 30.8% from 25-44, 19.4% from 45-64, and 10.4% who are 65 years of age or older. The median age is 32 years. In San Antonio, 48% of the population is male, and 52% of the population is female.

Cardiology/Vascular Diseases
Dermatology/Plastic Surgery
Endocrinology
Gastroenterology
Immunology/Infectious Diseases
Musculoskeletal
Nephrology/Urology
Pulmonary/Respiratory Diseases
Rheumatology