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We've found
10,036 Brain Cancer
clinical trials

Glioblastoma Clinical Trial
NovoTTF Treatment Signatures in Glioblastoma Patients at Autopsy
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Milwaukee, WI
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Glioblastoma Clinical Trial
CART-EGFRvIII + Pembrolizumab in GBM
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Nivolumab in People With IDH-Mutant Gliomas With and Without Hypermutator Phenotype
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Bethesda, MD
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Oncology Clinical Trial
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Status: Enrolling
Updated: 12/31/1969
mi
from
San Francisco, CA
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Neurology, Oncology Clinical Trial
Evaluation of Safety and Efficacy of ProHance in Pediatric Patients
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Charleston, SC
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Oncology Clinical Trial
9-ING-41 in Patients With Advanced Cancers
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Providence, RI
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Oncology Clinical Trial
9-ING-41 in Patients With Advanced Cancers
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
San Francisco, CA
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Oncology Clinical Trial
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Tampa, FL
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Oncology Clinical Trial
Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Los Angeles, CA
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Neuroendocrine Tumors Clinical Trial
A Study to Test the Effectiveness of ABI-009 in Patients With Metastatic, Unresectable, Low or Intermediate Grade Neuroendocrine Tumors of the Lung or Gastroenteropancreatic System
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
New Orleans, LA
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Oncology Clinical Trial
Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Pheochromocytoma/Paraganglioma
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
New York, NY
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Glioma Clinical Trial
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption
Status: Enrolling
Updated: 12/31/1969
mi
from
Baltimore, MD
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Oncology Clinical Trial
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Duarte, CA
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Oncology Clinical Trial
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Madison, WI
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Oncology Clinical Trial
A Study Utilizing Escitalopram in Glioma Patients
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Omaha, NE
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Oncology Clinical Trial
Validation of Readiband™ Actigraph and Associated Sleep/Wake Classification Algorithms
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Minneapolis, MN
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Dermatology / Plastic Surgery, Oncology Clinical Trial
Phase I/II Study of MEK162 for Children With Ras/Raf Pathway Activated Tumors
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Houston, TX
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Dermatology / Plastic Surgery, Oncology Clinical Trial
Phase I/II Study of MEK162 for Children With Ras/Raf Pathway Activated Tumors
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Miami, FL
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Dermatology / Plastic Surgery, Oncology Clinical Trial
Phase I/II Study of MEK162 for Children With Ras/Raf Pathway Activated Tumors
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Seattle, WA
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Refractory Brain Tumors Clinical Trial
Study of Busulfan for Refractory Central Nervous System (CNS) Tumors
Status: Upcoming, Phase I
Updated: 2/3/2009
mi
from
Chicago, IL
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Oncology Clinical Trial
Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
Status: Upcoming, Phase I
Updated: 10/16/2014
mi
from
Philadelphia, PA
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Glioblastoma Clinical Trial
Correlation Between Genetic and Imaging Information in Patients With Newly Diagnosed Glioblastoma Before Surgery
Status: Upcoming
Updated: 10/27/2015
mi
from
Columbus, OH
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Oncology Clinical Trial
Multi-site Validation and Application of a Consensus DSC-MRI Protocol
Status: Upcoming
Updated: 1/9/2018
mi
from
Milwaukee, WI
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Central Nervous System Neoplasms, Primary Clinical Trial
Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma
Status: Upcoming
Updated: 12/31/1969
mi
from
Kansas City, MO
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Intracranial Glioma Clinical Trial
Awake vs. Asleep Craniotomy for Non-eloquent Gliomas
Status: Upcoming
Updated: 12/31/1969
mi
from
Jacksonville, FL
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Oncology Clinical Trial
131I-Metaiodobenzylguanidine (131I-MIBG) Therapy for Relapsed/Refractory Neuroblastoma
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Dallas, TX
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Salt Lake City, UT
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
San Francisco, CA
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Columbus, OH
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Memphis, TN
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Boston, MA
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Chicago, IL
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Minneapolis, MN
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Primary Brain Neoplasm Clinical Trial
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Houston, TX
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Oncology Clinical Trial
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Columbus, OH
Click here to add this to my saved trials
Oncology Clinical Trial
Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Buffalo, NY
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Oncology Clinical Trial
18-F-Fluoroacetate as PET Imaging Agent
Status: Upcoming, Phase I
Updated: 6/12/2014
mi
from
Houston, TX
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Liver Cancer Clinical Trial
Phase 1 TheraSphere + Everolimus With Neuroendocrine Tumors (NETs) + Liver Only or Liver Dominant Disease
Status: Upcoming, Phase I
Updated: 1/21/2014
mi
from
Houston, TX
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Oncology Clinical Trial
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: Upcoming, Phase II
Updated: 10/30/2015
mi
from
Ann Arbor, MI
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Oncology Clinical Trial
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: Upcoming, Phase II
Updated: 10/30/2015
mi
from
Atlanta, GA
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Oncology Clinical Trial
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: Upcoming, Phase II
Updated: 10/30/2015
mi
from
Atlanta, GA
Click here to add this to my saved trials
Oncology Clinical Trial
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: Upcoming, Phase II
Updated: 10/30/2015
mi
from
Detroit, MI
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Brain Tumor Clinical Trial
Fluoro-L-Thymidine Positron Emission Tomography (FLT PET) vs. Adv. Magnetic Resonance (MR) Techniques in Recurrent Glioma
Status: Upcoming
Updated: 5/7/2015
mi
from
Houston, TX
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Neuroblastoma Clinical Trial
3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA
Status: Upcoming, Phase I
Updated: 12/18/2015
mi
from
Houston, TX
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Brain Tumor Clinical Trial
Demeclocycline Fluorescence for Intraoperative Delineation Brain Tumors
Status: Upcoming, Phase I
Updated: 4/12/2016
mi
from
Boston, MA
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Malignant Glioma of Brain Clinical Trial
Phase I Study of Safety and Tolerability of Acetazolamide With Temozolomide
Status: Upcoming, Phase I
Updated: 4/23/2018
mi
from
Chicago, IL
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Intracranial Glioma Clinical Trial
Awake vs. Asleep Craniotomy for Non-eloquent Gliomas
Status: Upcoming
Updated: 12/31/1969
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
Oncology Clinical Trial
Dendritic Cell Therapy for Brain Metastases From Breast- or Lung Cancer
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Charlestown, MA
Click here to add this to my saved trials
Oncology Clinical Trial
DM-CHOC-PEN for Brain Tumors in AYA Subjects
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
New Orleans, LA
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Oncology Clinical Trial
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning For a Short Course of Proton Beam Radiation Therapy
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Rochester, MN
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Oncology Clinical Trial
Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
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Oncology Clinical Trial
Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Seattle, WA
Click here to add this to my saved trials
Oncology Clinical Trial
Fimepinostat in Treating Brain Tumors in Children and Young Adults
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
San Francisco, CA
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Central Nervous System Tumors Clinical Trial
OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas
Status: Upcoming, Phase I
Updated: 1/19/2010
mi
from
Morgantown, WV
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Oncology Clinical Trial
Bevacizumab With or Without Surgery for Adult Glioblastomas
Status: Upcoming
Updated: 7/4/2013
mi
from
Bethesda, MD
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Oncology Clinical Trial
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: Upcoming, Phase II
Updated: 10/30/2015
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Glioblastoma Clinical Trial
Ph II Cilengitide Plus Bevacizumab for Recurrent Glioblastoma (GBM)
Status: Upcoming
Updated: 3/1/2013
mi
from
Houston, TX
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Malignant Glioma Clinical Trial
Patient Satisfaction, Efficacy and Compliance of Antiemetic Patch vs Pill in Malignant Glioma Patients
Status: Upcoming, Phase II
Updated: 3/4/2014
mi
from
Durham, NC
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Oncology Clinical Trial
Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Status: Upcoming, Phase II
Updated: 1/30/2014
mi
from
Arcadia, CA
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Oncology Clinical Trial
68Ga-DOTATATE PET Scan Imaging in Patients With Neuroendocrine Tumors
Status: Upcoming, Phase I, II
Updated: 1/16/2014
mi
from
Kenner, LA
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Oncology Clinical Trial
Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas
Status: Upcoming, Phase I
Updated: 2/3/2014
mi
from
Duarte, CA
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Oncology Clinical Trial
EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma
Status: Upcoming, Phase I, II
Updated: 8/11/2015
mi
from
Detroit, MI
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Oncology Clinical Trial
Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Saint Louis, MO
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Oncology Clinical Trial
Multi-site Validation and Application of a Consensus DSC-MRI Protocol
Status: Upcoming
Updated: 1/9/2018
mi
from
Providence, RI
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Oncology Clinical Trial
Multi-site Validation and Application of a Consensus DSC-MRI Protocol
Status: Upcoming
Updated: 1/9/2018
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
Glioblastoma Clinical Trial
DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Durham, NC
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Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Portland, OR
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Baltimore, MD
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
New Haven, CT
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Neuroblastoma Clinical Trial
Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Chapel Hill, NC
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Oncology Clinical Trial
Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Portland, OR
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Brain Cancer Clinical Trial
Phase I/II Cabazitaxel for Recurrent Malignant Glioma
Status: Upcoming
Updated: 11/30/2012
mi
from
Houston, TX
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Glioblastoma Clinical Trial
Peptide Vaccine for Glioblastoma Against Cytomegalovirus Antigens
Status: Upcoming, Phase I
Updated: 9/12/2013
mi
from
Gainesville, FL
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Pediatric Brain Tumor Clinical Trial
Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Oncology Clinical Trial
Vaccine Therapy and Cytokine-Induced Killer Cells in Treating Patients With Recurrent Glioblastoma
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Rochester, MN
Click here to add this to my saved trials
Childhood CNS Tumor Clinical Trial
SGT-53 in Children With Recurrent or Progressive CNS Malignancies
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Washington DC,
Click here to add this to my saved trials
Pituitary Neoplasm Clinical Trial
Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Bethesda, MD
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Malignant Brain Neoplasm Clinical Trial
Feasibility of FMISO in Brain Tumors
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Portland, OR
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Oncology Clinical Trial
C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma (GAIL-N)
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Houston, TX
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Oakland, CA
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
San Diego, CA
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Washington DC,
Click here to add this to my saved trials
Oncology, Psychiatry / Psychology Clinical Trial
BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain
Status: Upcoming
Updated: 3/11/2013
mi
from
Portland, OR
Click here to add this to my saved trials
Oncology Clinical Trial
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: Upcoming, Phase II
Updated: 10/30/2015
mi
from
Atlanta, GA
Click here to add this to my saved trials
Glioblastoma Clinical Trial
Correlation Between Genetic and Imaging Information in Patients With Newly Diagnosed Glioblastoma Before Surgery
Status: Upcoming
Updated: 10/27/2015
mi
from
Charleston, SC
Click here to add this to my saved trials
Oncology Clinical Trial
Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen Vaccine and Nivolumab in Treating Patients With Recurrent Glioblastoma
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Oncology Clinical Trial
Epacadostat in Combination With Radiation Therapy and Avelumab in Patients With Recurrent Gliomas
Status: Upcoming, Phase I, II
Updated: 12/31/1969
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Intracranial Glioma Clinical Trial
Awake vs. Asleep Craniotomy for Non-eloquent Gliomas
Status: Upcoming
Updated: 12/31/1969
mi
from
Rochester, MN
Click here to add this to my saved trials
Pediatric Brain Tumor Clinical Trial
Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Saint Louis, MO
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Oncology Clinical Trial
Trial of C134 in Patients With Recurrent GBM
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Birmingham, AL
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Oncology Clinical Trial
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases
Status: Upcoming
Updated: 12/31/1969
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Houston, TX
Click here to add this to my saved trials
Oncology Clinical Trial
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Seattle, WA
Click here to add this to my saved trials
Oncology Clinical Trial
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning For a Short Course of Proton Beam Radiation Therapy
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
Glioma of Brain Clinical Trial
Early Temozolomide in Patients With High-Grade Gliomas in Rehabilitation
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Rochester, NY
Click here to add this to my saved trials
Oncology Clinical Trial
Biologically-based Target Volumes to Treat Newly Diagnosed Glioblastoma
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Iowa City, IA
Click here to add this to my saved trials
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