Colorado Clinical Trials

Are you looking to enroll in a clinical trial in Colorado? With new trials like "A Phase 1b Study of Demcizumab Plus Pembrolizumab in Locally Advanced or Metastatic Solid Tumors" and "A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus", the Centennial State has established itself as a great location for clinical research studies, particularly in cities like Aurora and Denver.

While some individuals are looking for paid clinical trials, others want to help advance pharmacology and urology clinical research in Colorado. To begin your search for Colorado clinical trials, use the form on the right.

Use our guide to learn which trials are right for you!


We've found
4,993
clinical trials in
Colorado

Oncology Clinical Trial
Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Golden, CO
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Oncology Clinical Trial
Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Littleton, CO
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Oncology Clinical Trial
Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Lone Tree, CO
Click here to add this to my saved trials
Oncology Clinical Trial
Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Pueblo, CO
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Head and Neck Neoplasms Clinical Trial
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
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Multiple Myeloma Clinical Trial
Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Denver, CO
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Oncology Clinical Trial
CTL019 Out of Specification MAP for ALL or DLBCL Patients
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Other, Reproductive Clinical Trial
Bone Mineral Density in Women With Uterine Fibroids or Endometriosis
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Denver, CO
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Cancer Clinical Trial
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Aurora, CO
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Diabetes Mellitus Clinical Trial
FreeStyle LIbre Flash Glucose Monitoring System Pediatric Accuracy Study
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Intraoperative Floppy Iris Syndrome Clinical Trial
Pupil Dilation for Treatment of IFIS
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
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Parkinson Disease Clinical Trial
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
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Hypoplastic Left Heart Syndrome Clinical Trial
Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome (AutoCell-S2)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
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Type 1 Diabetes Mellitus Clinical Trial
A Study Comparing LY900014 to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes Using Insulin Pump Therapy
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Oncology Clinical Trial
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Durango, CO
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Oncology Clinical Trial
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Lakewood, CO
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Oncology Clinical Trial
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Littleton, CO
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Oncology Clinical Trial
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Parker, CO
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Degenerative Osteoarthritis Clinical Trial
Propionibacterium Dermal Colonization: Implications for Total Hip Arthroplasty
Status: Enrolling
Updated: 12/31/1969
mi
from
Denver, CO
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Disc Degeneration;Cervical Clinical Trial
The NanoStrand Clinical Study
Status: Enrolling
Updated: 12/31/1969
mi
from
Durango, CO
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Oncology Clinical Trial
Firstline Pembrolizumab Alone or in Combination With Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Denver, CO
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Oncology Clinical Trial
Firstline Pembrolizumab Alone or in Combination With Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Denver, CO
Click here to add this to my saved trials
Palmar Hyperhidrosis Clinical Trial
A Study of Glycopyrronium Cloth, 2.4% in Patients With Palmar Hyperhidrosis
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
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Urothelial Carcinoma Clinical Trial
Trebananib (AMG 386) in Combination With Docetaxel for Advanced Urothelial Carcinoma
Status: Upcoming, Phase II
Updated: 12/23/2013
mi
from
Aurora, CO
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Hip Labral Tear Clinical Trial
Study of RNS60 on Pain and Function After Hip Labral Repair
Status: Upcoming, Phase II
Updated: 7/24/2014
mi
from
Vail, CO
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Unstable Corneas Clinical Trial
Corneal Cross-Linking Comparing Variables
Status: Upcoming, Phase III
Updated: 3/21/2014
mi
from
Denver, CO
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Advanced Biliary Tract Cancer Clinical Trial
A Randomized, Open-Label, Comparative, Parallel-Group, Multicenter Study of SPARC1507
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
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Gastroenterology, Immunology / Infectious Diseases, Rheumatology Clinical Trial
Effect of Reducing Nucleotide Exposure on Bone Health (ReNew)
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
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Oncology Clinical Trial
An Investigational Immuno-therapy Study of Relatlimab Plus Nivolumab Compared to Various Standard-of-Care Therapies in Previously Treated Participants With Recurrent, Advanced or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
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Cholecystitis, Acute Clinical Trial
AXIOS™ for Gallbladder Drainage as an Alternative to Percutaneous Drainage IDE
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Endocrinology, Gastroenterology, Reproductive Clinical Trial
Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Idiopathic Pulmonary Fibrosis (IPF) Clinical Trial
Inhaled NAC in Treatment of IPF
Status: Upcoming, Phase I, II
Updated: 12/31/1969
mi
from
Aurora, CO
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Acute Graft-versus-Host Disease Clinical Trial
Safety and Efficacy of Itacitinib in Combination With Corticosteroids for Treatment of Graft-Versus-Host Disease in Pediatric Subjects
Status: Upcoming, Phase I, II
Updated: 12/31/1969
mi
from
Aurora, CO
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HIV INfections Clinical Trial
The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less Than 12 Years of Age
Status: Upcoming, Phase I, II
Updated: 12/31/1969
mi
from
Aurora, CO
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Parkinson Disease Clinical Trial
Wearable Assessments in the Clinic and Home in PD
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Prostatic Neoplasms Clinical Trial
A Study of Apalutamide in Participants With High‑Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Denver, CO
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HIV INfections Clinical Trial
Long-Acting Cabotegravir Plus VRC01LS for Viral Suppression in Adults Living With HIV-1
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Type 1 Diabetes Mellitus Clinical Trial
A Study of t:Slim X2 With Control-IQ Technology
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Neurology Clinical Trial
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Premature Birth Clinical Trial
Vaginal Progesterone in Twins With Short Cervix
Status: Upcoming, Phase II, III
Updated: 9/30/2013
mi
from
Denver, CO
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Cardiology / Vascular Diseases Clinical Trial
Treatment of Exercise-Induced Pulmonary Vascular Dysfunction in Symptomatic Patients After Pulmonary Thromboendarterectomy
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Solid Tumor, Adult Clinical Trial
Assessing the Combination of Durvalumab (MEDI4736) and Trabectedin in Solid Tumors
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Aurora, CO
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Smith-Lemli-Opitz Syndrome Clinical Trial
Smith-Lemli-Opitz Syndrome and Cholic Acid
Status: Upcoming, Phase I, II
Updated: 12/31/1969
mi
from
Aurora, CO
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Colorectal Cancer Clinical Trial
Predictors of Physical Activity Maintenance in Colorectal Cancer Survivors
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Pediatric Neurosurgical Tumors Clinical Trial
Sodium Fluorescein-Guided Resection of Pediatric Neurosurgical Tumors
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Hyperinsulinemic Hypoglycemia Clinical Trial
Glucagon Ready to Use (RTU) in Subjects With Hyperinsulinemic Hypoglycemia After Bariatric Surgery
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Endocrinology Clinical Trial
Comparing High and Normal Protein Diets for the Dietary Remission of Type 2 Diabetes
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Cardiology / Vascular Diseases Clinical Trial
Enhancing Cardiac Rehabilitation Through Behavioral Nudges
Status: Upcoming
Updated: 12/31/1969
mi
from
Denver, CO
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Neurology, Other Clinical Trial
Efficacy and Safety of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Liver Cancer Clinical Trial
Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Oncology Clinical Trial
Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
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Schizophrenia Clinical Trial
FMRI of Cholinergic Mechanisms in Schizophrenia
Status: Upcoming
Updated: 7/25/2012
mi
from
Denver, CO
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Psychiatry / Psychology Clinical Trial
Phosphatidylcholine Supplementation in Infants
Status: Upcoming, Phase I, II
Updated: 3/23/2016
mi
from
Aurora, CO
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Anterior Cruciate Ligament Reconstruction Clinical Trial
Study of RNS60 on Pain and Function After Knee Anterior Cruciate Ligament Surgery
Status: Upcoming, Phase II
Updated: 7/24/2014
mi
from
Vail, CO
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Colonic Neoplasms Clinical Trial
Metabiomics Colon Cancer Clinical Research Study
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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HIV INfections Clinical Trial
Safety, Tolerability, Drug Interactions, and Antiviral Activity of Rilpivirine in Antiretroviral-Naive HIV-Infected Children Less Than 12 Years of Age
Status: Upcoming, Phase I, II
Updated: 11/24/2014
mi
from
Aurora, CO
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Giant Cell Arteritis Clinical Trial
A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA)
Status: Upcoming, Phase III
Updated: 6/19/2017
mi
from
Denver, CO
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Immunology / Infectious Diseases, Reproductive Clinical Trial
VF Test for Prediction of Extremely PTB After Cerclage
Status: Upcoming
Updated: 2/16/2018
mi
from
Denver, CO
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Peritoneal Dialysis Complication Clinical Trial
EMT in Peritoneal Dialysis Patients
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Pulmonary / Respiratory Diseases Clinical Trial
Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
Click here to add this to my saved trials
HIV INfections Clinical Trial
The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Acute Ischemic Stroke Clinical Trial
Multi-arm Optimization of Stroke Thrombolysis
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Englewood, CO
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Primary Biliary Cholangitis Clinical Trial
A Study of Baricitinib (LY3009104) in Participants With Primary Biliary Cholangitis Who do Not Respond or Cannot Take UDCA
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Type 1 Diabetes Mellitus Clinical Trial
A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Colorectal Cancer Clinical Trial
Predictors of Physical Activity Maintenance in Colorectal Cancer Survivors
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Fort Collins, CO
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Clinical Trial
DWI Offenders and Their Families App for Smartphones
Status: Upcoming
Updated: 12/31/1969
mi
from
Golden, CO
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Rheumatology, Orthopedics / Podiatry Clinical Trial
Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Aurora, CO
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Nephrology / Urology Clinical Trial
Clinical Trial to Slow the Progression of ADPKD
Status: Upcoming
Updated: 11/2/2005
mi
from
Denver, CO
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Schizophrenia Clinical Trial
FMRI of Cholinergic Mechanisms in Schizophrenia
Status: Upcoming
Updated: 7/25/2012
mi
from
Denver, CO
Click here to add this to my saved trials
Pyridoxine Dependant Epilepsy Clinical Trial
Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients
Status: Upcoming
Updated: 8/23/2013
mi
from
Aurora, CO
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HIV/AIDS Clinical Trial
Darunavir/Cobicistat and Dolutegravir to Maintain Virologic Suppression and Reduce NRTI-associated Toxicity
Status: Upcoming, Phase II, III
Updated: 7/14/2015
mi
from
Aurora, CO
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Oximetry Clinical Trial
Accuracy Validation of a Pulse Oximetry Monitor
Status: Upcoming
Updated: 2/25/2016
mi
from
Louisville, CO
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Renal Transplant Patients Clinical Trial
CNS Study of Patients Switching From Tacrolimus to Envarsus
Status: Upcoming, Phase IV
Updated: 10/27/2017
mi
from
Aurora, CO
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Cystic Fibrosis-related Diabetes Clinical Trial
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Huntington Disease Clinical Trial
FuRST 2.0 Cognitive Pre-testing - Round 2
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Englewood, CO
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HIV-1-infection Clinical Trial
Pharmacokinetics of SAR441236
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Aurora, CO
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Colorectal Cancer Clinical Trial
Immunotherapy Combined With Y-90 and SBRT for Colorectal Liver Metastases
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Macular Degeneration Clinical Trial
Comparing the Efficacy and Safety of Biosimilar Candidate Xlucane Versus Lucentis® in Patients With nAMD
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Golden, CO
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HIV INfections Clinical Trial
Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in HIV-1-infected Participants on Suppressive cART
Status: Upcoming, Phase I, II
Updated: 12/31/1969
mi
from
Aurora, CO
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Infant Development Clinical Trial
Early Iron Exposure on the Gut Microbiota in Young Infants
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Von Willebrand Diseases Clinical Trial
ATHN 9: Severe VWD Natural History Study
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Endocrinology, Nephrology / Urology Clinical Trial
Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Aurora, CO
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Remote Monitoring Clinical Trial
Effectiveness and Costs of Remote Monitoring for Clinical Trials
Status: Upcoming
Updated: 6/28/2010
mi
from
Denver, CO
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Hypertension Clinical Trial
Aliskiren Study of Safety and Efficacy in Senior Hypertensives
Status: Upcoming, Phase IV
Updated: 1/5/2015
mi
from
Denver, CO
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Persistence of Varicella Immunity Clinical Trial
Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine
Status: Upcoming, Phase IV
Updated: 12/31/1969
mi
from
Aurora, CO
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Asthma Clinical Trial
Study of Efficacy and Safety of NVA237 in Patients With Poorly Controlled Asthma
Status: Upcoming, Phase III
Updated: 5/21/2014
mi
from
Colorado Springs, CO
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Reproductive Clinical Trial
Study of the Safety and Efficacy of Ulipristal Acetate (UPA) Used Daily as a Contraceptive
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
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NAFLD Clinical Trial
Copeptin and Nonalcoholic Fatty Liver Disease
Status: Upcoming, Phase
Updated: 12/31/1969
mi
from
Aurora, CO
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Chronic Illness Clinical Trial
Virtually-integrated Co-management Between Complex Care and Community-based Primary Care Providers
Status: Upcoming
Updated: 12/31/1969
mi
from
Aurora, CO
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Immunology / Infectious Diseases, Pulmonary / Respiratory Diseases Clinical Trial
Trial of Inhaled Molgramostim in CF Subjects With NTM Infection
Status: Upcoming, Phase II
Updated: 12/31/1969
mi
from
Denver, CO
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Contraception Clinical Trial
Antepartum Etonogestrel Contraceptive Implant Insertion at Term
Status: Upcoming, Phase I
Updated: 12/31/1969
mi
from
Aurora, CO
Click here to add this to my saved trials
Migraine Clinical Trial
A Study of Lasmiditan (LY573144) Over Four Migraine Attacks
Status: Upcoming, Phase III
Updated: 12/31/1969
mi
from
Englewood, CO
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Aging Clinical Trial
Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults
Status: Upcoming
Updated: 12/31/1969
mi
from
Boulder, CO
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Dermatology / Plastic Surgery, Endocrinology, Immunology / Infectious Diseases, Other Clinical Trial
A Complicated Skin and Soft-Tissue Infection Patient Registry
Status: Enrolling
Updated: 2/27/2009
mi
from
Aurora, CO
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Brain and Central Nervous System Tumors Clinical Trial
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Colorado Springs, CO
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Type 2 Diabetes Mellitus Clinical Trial
Colesevelam Pediatric Type 2 Diabetes Mellitus Study
Status: Enrolling, Phase IV
Updated: 12/22/2017
mi
from
Aurora, CO
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Pediatric Acute Myelogenous Leukemia (AML) Clinical Trial
Efficacy and Safety of Decitabine as Epigenetic Priming With Induction Chemotherapy in Pediatric Acute Myelogenous Leukemia (AML) Subjects
Status: Enrolling
Updated: 12/6/2012
mi
from
Aurora, CO
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Orthopedics / Podiatry Clinical Trial
Web Based Orthopaedic Sports Medicine Registry
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Steamboat Springs, CO
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Multiple Sclerosis Clinical Trial
Safety Study in Patients With Multiple Sclerosis Treated Fingolimod or Other Approved Disease-modifying Therapies
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Louisville, CO
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Cardiology / Vascular Diseases, Gastroenterology, Nephrology / Urology, Neurology Clinical Trial
Product Surveillance Registry
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Lakewood, CO
Click here to add this to my saved trials
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